Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma.
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ABSTRACT:
SUBMITTER: Yachida S
PROVIDER: S-EPMC5503303 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma.
Yachida Shinichi S Wood Laura D LD Suzuki Masami M Takai Erina E Totoki Yasushi Y Kato Mamoru M Luchini Claudio C Arai Yasuhito Y Nakamura Hiromi H Hama Natsuko N Elzawahry Asmaa A Hosoda Fumie F Shirota Tomoki T Morimoto Nobuhiko N Hori Kunio K Funazaki Jun J Tanaka Hikaru H Morizane Chigusa C Okusaka Takuji T Nara Satoshi S Shimada Kazuaki K Hiraoka Nobuyoshi N Taniguchi Hirokazu H Higuchi Ryota R Oshima Minoru M Okano Keiichi K Hirono Seiko S Mizuma Masamichi M Arihiro Koji K Yamamoto Masakazu M Unno Michiaki M Yamaue Hiroki H Weiss Matthew J MJ Wolfgang Christopher L CL Furukawa Toru T Nakagama Hitoshi H Vogelstein Bert B Kiyono Tohru T Hruban Ralph H RH Shibata Tatsuhiro T
Cancer cell 20160121 2
Ampullary carcinomas are highly malignant neoplasms that can have either intestinal or pancreatobiliary differentiation. To characterize somatic alterations in ampullary carcinomas, we performed whole-exome sequencing and DNA copy-number analysis on 60 ampullary carcinomas resected from clinically well-characterized Japanese and American patients. We next selected 92 genes and performed targeted sequencing to validate significantly mutated genes in an additional 112 cancers. The prevalence of dr ...[more]
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