Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC5503501 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Zhang Jianxu J Wang Yudi Y Chen Jiawen J Liang Xiao X Han Haobo H Yang Yan Y Li Quanshun Q Wang Yanbo Y
International journal of nanomedicine 20170703
Herein, DNA duplex was constructed through the hybridization of adenosine triphosphate (ATP)-responsive aptamer and its cDNA in which GC-rich motif could be used to load doxorubicin (DOX), and then, cationic polymer PEI25K was used as a carrier to simultaneously condense DOX-Duplex and Bcl-2 siRNA to prepare the ternary nanocomplex polyethylenimine (PEI)/DOX-Duplex/siRNA. The ATP concentration gradient between the cytosol and extracellular environment could achieve the stable loading of DOX in d ...[more]