Ontology highlight
ABSTRACT:
SUBMITTER: Libouban MAA
PROVIDER: S-EPMC5503534 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Libouban Marion A A MAA de Roos Jeroen A D M JADM Uitdehaag Joost C M JCM Willemsen-Seegers Nicole N Mainardi Sara S Dylus Jelle J de Man Jos J Tops Bastiaan B Tops Bastiaan B Meijerink Jules P P JPP Storchová Zuzana Z Buijsman Rogier C RC Medema René H RH Zaman Guido J R GJR
Oncotarget 20170601 24
Inhibition of the spindle assembly checkpoint kinase TTK causes chromosome mis-segregation and tumor cell death. However, high levels of TTK correlate with chromosomal instability (CIN), which can lead to aneuploidy. We show that treatment of tumor cells with the selective small molecule TTK inhibitor NTRC 0066-0 overrides the mitotic checkpoint, irrespective of cell line sensitivity. In stable aneuploid cells NTRC 0066-0 induced acute CIN, whereas in cells with high levels of pre-existing CIN t ...[more]