Ontology highlight
ABSTRACT:
SUBMITTER: Michelucci A
PROVIDER: S-EPMC5503704 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Michelucci Antonio A Paolini Cecilia C Boncompagni Simona S Canato Marta M Reggiani Carlo C Protasi Feliciano F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20170502 8
In humans, hyperthermic episodes can be triggered by halogenated anesthetics [malignant hyperthermia (MH) susceptibility] and by high temperature [environmental heat stroke (HS)]. Correlation between MH susceptibility and HS is supported by extensive work in mouse models that carry a mutation in ryanodine receptor type-1 (RYR1<sup>Y522S/WT</sup>) and calsequestrin-1 knockout (CASQ1-null), 2 proteins that control Ca<sup>2+</sup> release in skeletal muscle. As overheating episodes in humans have a ...[more]