Ontology highlight
ABSTRACT:
SUBMITTER: Tanner MR
PROVIDER: S-EPMC5503717 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Tanner Mark R MR Pennington Michael W MW Laragione Teresina T Gulko Pércio S PS Beeton Christine C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20170420 8
Large-conductance calcium-activated potassium channel (KCa1.1; BK, Slo1, MaxiK, <i>KCNMA1</i>) is the predominant potassium channel expressed at the plasma membrane of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) isolated from the synovium of patients with RA. It is a critical regulator of RA-FLS migration and invasion and therefore represents an attractive target for the therapy of RA. However, the molecular mechanisms by which KCa1.1 regulates RA-FLS invasiveness have remained l ...[more]