Ontology highlight
ABSTRACT:
SUBMITTER: Raasakka A
PROVIDER: S-EPMC5504075 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20170710 1
Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between two cytoplasmic leaflets of stacked myelin membranes, mostly occupied by a myelin basic protein (MBP) phase. MBP is an abundant myelin protein involved in demyelinating diseases, such as multiple sclerosis. The association of MBP with lipid membranes has been studied for decades, but the MBP-driven f ...[more]