Ontology highlight
ABSTRACT:
SUBMITTER: Bins S
PROVIDER: S-EPMC5504481 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Bins S S van Doorn L L Phelps M A MA Gibson A A AA Hu S S Li L L Vasilyeva A A Du G G Hamberg P P Eskens Falm F de Bruijn P P Sparreboom A A Mathijssen Rhj R Baker S D SD
Clinical and translational science 20170331 4
The oral multikinase inhibitor sorafenib undergoes extensive UGT1A9-mediated formation of sorafenib-β-D-glucuronide (SG). Using transporter-deficient mouse models, it was previously established that SG can be extruded into bile by ABCC2 or follow a liver-to-blood shuttling loop via ABCC3-mediated efflux into the systemic circulation, and subsequent uptake in neighboring hepatocytes by OATP1B-type transporters. Here we evaluated the possibility that this unusual process, called hepatocyte hopping ...[more]