Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC5505065 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Chen Zekun Z Wu Qiuju Q Ding Ye Y Zhou Wenhui W Liu Rong R Chen Haiying H Zhou Jia J Feng Jing J Chen Ceshi C
Theranostics 20170611 8
Triple-negative breast cancer (TNBC) is an aggressive malignancy with poor clinical outcomes. YD277 is a novel small molecule derived from ML264, a KLF5 inhibitor that elicits cytotoxic effects in colon cancer cell lines. Our previous studies suggest that Krüpple-like factor 5 (KLF5) is a promising therapeutic target for TNBC. In this study, we demonstrated that YD277 significantly induced G1 cell cycle arrest and apoptosis in MDA-MB-231 and MDA-MB-468 TNBC cells, independent of KLF5 inhibition. ...[more]