Ontology highlight
ABSTRACT:
SUBMITTER: Jadhav U
PROVIDER: S-EPMC5505276 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Jadhav Unmesh U Saxena Madhurima M O'Neill Nicholas K NK Saadatpour Assieh A Yuan Guo-Cheng GC Herbert Zachary Z Murata Kazutaka K Shivdasani Ramesh A RA
Cell stem cell 20170622 1
Replicating Lgr5<sup>+</sup> stem cells and quiescent Bmi1<sup>+</sup> cells behave as intestinal stem cells (ISCs) in vivo. Disrupting Lgr5<sup>+</sup> ISCs triggers epithelial renewal from Bmi1<sup>+</sup> cells, from secretory or absorptive progenitors, and from Paneth cell precursors, revealing a high degree of plasticity within intestinal crypts. Here, we show that GFP<sup>+</sup> cells from Bmi1<sup>GFP</sup> mice are preterminal enteroendocrine cells and we identify CD69<sup>+</sup>CD274< ...[more]