Ontology highlight
ABSTRACT:
SUBMITTER: Chauhan AK
PROVIDER: S-EPMC5505339 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20170512 12
Recognition of Ab-opsonized pathogens by immune cells triggers both TLR and Fc receptor signaling. Fc receptors endocytose modified nucleic acids bound to Abs and deliver them to endosomes, where they are recognized by nucleic acid-sensing TLRs (NA-TLRs). We show that in CD4<sup>+</sup> T cells, NA-TLRs, TLR3, TLR8, and TLR9 are upregulated by FcγRIIIa-pSyk cosignaling and localize with FcγRIIIa on the cell surface. TLR9 accumulates on the cell surface, where it recognizes CpG oligonucleotide 20 ...[more]