Ontology highlight
ABSTRACT:
SUBMITTER: Yackle K
PROVIDER: S-EPMC5505554 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Yackle Kevin K Schwarz Lindsay A LA Kam Kaiwen K Sorokin Jordan M JM Huguenard John R JR Feldman Jack L JL Luo Liqun L Krasnow Mark A MA
Science (New York, N.Y.) 20170330 6332
Slow, controlled breathing has been used for centuries to promote mental calming, and it is used clinically to suppress excessive arousal such as panic attacks. However, the physiological and neural basis of the relationship between breathing and higher-order brain activity is unknown. We found a neuronal subpopulation in the mouse preBötzinger complex (preBötC), the primary breathing rhythm generator, which regulates the balance between calm and arousal behaviors. Conditional, bilateral genetic ...[more]