Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC5505639 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Wang Hansong H Schmit Stephanie L SL Haiman Christopher A CA Keku Temitope O TO Kato Ikuko I Palmer Julie R JR van den Berg David D Wilkens Lynne R LR Burnett Terrilea T Conti David V DV Schumacher Fredrick R FR Signorello Lisa B LB Blot William J WJ Zanetti Krista A KA Harris Curtis C Pande Mala M Berndt Sonja I SI Newcomb Polly A PA West Dee W DW Haile Robert R Stram Daniel O DO Figueiredo Jane C JC Le Marchand Loïc L
International journal of cancer 20170328 12
Genome-wide association studies (GWAS) in ethnic/racial minority populations can help to fine-map previously identified risk regions or discover new risk loci because of the genetic diversity in these populations. We conducted a GWAS of colorectal cancer (CRC) in 6,597 African Americans (1,894 cases and 4,703 controls) (Stage 1) and followed up the most promising markers in a replication set of 2,041 participants of African descent (891 cases and 1,150 controls) (Stage 2). We identified a novel ...[more]