Ontology highlight
ABSTRACT:
SUBMITTER: Sogi KM
PROVIDER: S-EPMC5505729 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Sogi Kimberly M KM Holsclaw Cynthia M CM Fragiadakis Gabriela K GK Nomura Daniel K DK Leary Julie A JA Bertozzi Carolyn R CR
ACS infectious diseases 20160815 11
Sulfomenaquinone (SMK) is a recently identified metabolite that is unique to the Mycobacterium tuberculosis (M. tuberculosis) complex and is shown to modulate its virulence. Here, we report the identification of the SMK biosynthetic operon that, in addition to a previously identified sulfotransferase stf3, includes a putative cytochrome P450 gene (cyp128) and a gene of unknown function, rv2269c. We demonstrate that cyp128 and stf3 are sufficient for the biosynthesis of SMK from menaquinone and r ...[more]