Ontology highlight
ABSTRACT:
SUBMITTER: Pizza FX
PROVIDER: S-EPMC5506053 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Pizza Francis X FX Martin Ryan A RA Springer Evan M EM Leffler Maxwell S MS Woelmer Bryce R BR Recker Isaac J IJ Leaman Douglas W DW
Scientific reports 20170711 1
The overall objective of the study was to identify mechanisms through which intercellular adhesion molecule-1 (ICAM-1) augments the adhesive and fusogenic properties of myogenic cells. Hypotheses were tested using cultured myoblasts and fibroblasts, which do not constitutively express ICAM-1, and myoblasts and fibroblasts forced to express full length ICAM-1 or a truncated form lacking the cytoplasmic domain of ICAM-1. ICAM-1 mediated myoblast adhesion and fusion were quantified using novel assa ...[more]