Ontology highlight
ABSTRACT:
SUBMITTER: Oppelt PJ
PROVIDER: S-EPMC5506287 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Journal of gastrointestinal oncology 20170601 3
The therapeutic implications of the genomic alterations seen within the drivers of gastrointestinal stromal tumors (GIST) are among the best understood in all of solid tumors. Sequencing of cKIT and PDGFRα should be considered standard practice for the treatment of GIST patients. In this article, we will review the common mutations and how they are utilized in clinical management. In addition, we will review the rare D842V PDGFRα mutation and the diverse molecular group that lacks a mutation in ...[more]