Ontology highlight
ABSTRACT:
SUBMITTER: Figueira MF
PROVIDER: S-EPMC5506523 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Figueira Miriam F MF Castiglione Raquel C RC de Lemos Barbosa Carolina M CM Ornellas Felipe M FM da Silva Feltran Geórgia G Morales Marcelo M MM da Fonseca Rodrigo N RN de Souza-Menezes Jackson J
Physiological reports 20170701 13
Diabetic nephropathy (DN) occurs in around 40% of those with diabetes. Proteinuria is the main characteristic of DN and develops as a result of increased permeability of the glomerulus capillary wall and/or decreased proximal tubule endocytosis. The goal of this work was to evaluate renal function and the expression of megalin, cubilin, CFTR (cystic fibrosis transmembrane conductance regulator), and ClC-5 in the proximal tubule and renal cortex of rats with type 1 diabetes. Male Wistar rats were ...[more]