Ontology highlight
ABSTRACT:
SUBMITTER: Alexander CM
PROVIDER: S-EPMC5506691 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Experimental lung research 20160401 3
Tumor promotion is an early and critical stage during lung adenocarcinoma (ADC). We previously demonstrated that Tlr4 mutant mice were more susceptible to butylated hydroxytoluene (BHT)-induced pulmonary inflammation and tumor promotion in comparison to Tlr4-sufficient mice. Our study objective was to elucidate the underlying differences in Tlr4 mutant mice in innate immune cell populations, their functional responses, and the influence of these cellular differences on ADC progenitor (type II) c ...[more]