Ontology highlight
ABSTRACT:
SUBMITTER: Ryan ML
PROVIDER: S-EPMC5506792 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Ryan Megan L ML Falk Daniel E DE Fertig Joanne B JB Rendenbach-Mueller Beatrice B Katz David A DA Tracy Katherine A KA Strain Eric C EC Dunn Kelly E KE Kampman Kyle K Mahoney Elizabeth E Ciraulo Domenic A DA Sickles-Colaneri Laurie L Ait-Daoud Nassima N Johnson Bankole A BA Ransom Janet J Scott Charles C Koob George F GF Litten Raye Z RZ
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20160923 5
Alcohol use disorder has been linked to dysregulation of the brain stress systems, producing a negative emotional state leading to chronic relapsing behavior. Vasopressin receptors appear to have a regulatory role in stress, anxiety, and alcohol. This study evaluated the novel compound, ABT-436, a V1b receptor antagonist, in alcohol-dependent participants in a 12-week clinical trial. Men and women (n=150) who met criteria for DSM-IV alcohol dependence were recruited across four sites. Participan ...[more]