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Preparation and Characterization of Thermoresponsive Poly(N-isopropylacrylamide-co-acrylic acid)-Grafted Hollow Fe?O?/SiO? Microspheres with Surface Holes for BSA Release.

ABSTRACT: Thermoresponsive P(NIPAM-AA)/Fe?O?/SiO? microspheres with surface holes serving as carriers were prepared using p-Fe?O?/SiO? microspheres with a thermoresponsive copolymer. The p-Fe?O?/SiO? microspheres was obtained using a modified Pickering method and chemical etching. The surface pore size of p-Fe?O?/SiO? microspheres was in the range of 18.3 nm~37.2 nm and the cavity size was approximately 60 nm, which are suitable for loading and transporting biological macromolecules. P(NIPAM-AA) was synthesized inside and outside of the p-Fe?O?/SiO? microspheres via atom transfer radical polymerization of NIPAM, MBA and AA. The volume phase transition temperature (VPTT) of the specifically designed P(NIPAM-AA)/Fe?O?/SiO? microspheres was 42.5 °C. The saturation magnetization of P(NIPAM-AA)/Fe?O?/SiO? microspheres was 72.7 emu/g. The P(NIPAM-AA)/Fe?O?/SiO? microspheres were used as carriers to study the loading and release behavior of BSA. This microsphere system shows potential for the loading of proteins as a drug delivery platform.

SUBMITTER: Zhao J 

PROVIDER: S-EPMC5506986 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Preparation and Characterization of Thermoresponsive Poly(N-isopropylacrylamide-co-acrylic acid)-Grafted Hollow Fe₃O₄/SiO₂ Microspheres with Surface Holes for BSA Release.

Zhao Jing J   Zeng Ming M   Zheng Kaiqiang K   He Xinhua X   Xie Minqiang M   Fu Xiaoyi X  

Materials (Basel, Switzerland) 20170414 4

Thermoresponsive P(NIPAM-AA)/Fe₃O₄/SiO₂ microspheres with surface holes serving as carriers were prepared using p-Fe₃O₄/SiO₂ microspheres with a thermoresponsive copolymer. The p-Fe₃O₄/SiO₂ microspheres was obtained using a modified Pickering method and chemical etching. The surface pore size of p-Fe₃O₄/SiO₂ microspheres was in the range of 18.3 nm~37.2 nm and the cavity size was approximately 60 nm, which are suitable for loading and transporting biological macromolecules. P(NIPAM-AA) was synth  ...[more]

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