Ontology highlight
ABSTRACT:
SUBMITTER: Wachsmuth LM
PROVIDER: S-EPMC5507555 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Wachsmuth Leah M LM Johnson Meredith G MG Gavenonis Jason J
PLoS neglected tropical diseases 20170629 6
Parasitic diseases caused by kinetoplastid parasites of the genera Trypanosoma and Leishmania are an urgent public health crisis in the developing world. These closely related species possess a number of multimeric enzymes in highly conserved pathways involved in vital functions, such as redox homeostasis and nucleotide synthesis. Computational alanine scanning of these protein-protein interfaces has revealed a host of potentially ligandable sites on several established and emerging anti-parasit ...[more]