Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5507668 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zhang Xu X Chen Xiaoli X Liu Qiuying Q Zhang Shaojie S Hu Wenqian W
eLife 20170621
Gene expression is precisely regulated during the inflammatory response to control infection and limit the detrimental effects of inflammation. Here, we profiled global mRNA translation dynamics in the mouse primary macrophage-mediated inflammatory response and identified hundreds of differentially translated mRNAs. These mRNAs' 3'UTRs have enriched binding motifs for several RNA-binding proteins, which implies extensive translational regulatory networks. We characterized one such protein, Zfp36 ...[more]