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A continuous-infusion dynamic MRI model at 3.0 Tesla for the serial quantitative evaluation of microvascular proliferation in an animal model of glioblastoma multiforme.

ABSTRACT: PURPOSE:To develop a continuous-infusion dynamic MRI technique to characterize tumor-associated microvascular proliferation (MVP) in a rat brain model of glioblastoma multiforme. METHODS:The proposed model assumes effects due to tumor-associated MVP (eg, vascular permeability, Ktrans ; intravascular plasma fraction, vp ) cannot be individually separated and solves for a single parameter (kvasc ) that quantifies the T1 -weighted contrast enhancement from dynamic images acquired during continuous contrast agent (CA) infusion. Untreated C6 tumor-bearing animals (N?=?6) were serially imaged on postoperative days (PODs) 14 and 18 with a 3 Tesla clinical scanner utilizing a dynamic spatial and temporal resolution of 0.38?×?0.38?×?1.5?mm3 and 3.47 s, respectively. RESULTS:An association was present between PODs 14 and 18 for median tumor kvasc (Pearson's r?=?0.94, P?=?0.0052) and CA concentration ([CA], derived from pre- and postcontrast R1 maps; r?=?0.94, P?=?0.0054). On POD 18, there was a voxel-based association between kvasc and [CA] within each tumor (0.45??0.05) or an inverse association (N?=?1; r?=?-0.28, P?=?0.001), indicating differences between locations of vascular permeability and subsequent CA pooling in tumors. CONCLUSION:The continuous-infusion method may provide a quantitative measure for characterizing and monitoring tumor-associated MVP. Magn Reson Med 78:1824-1838, 2017. © 2017 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Underhill HR

PROVIDER: S-EPMC5507763 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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A continuous-infusion dynamic MRI model at 3.0 Tesla for the serial quantitative evaluation of microvascular proliferation in an animal model of glioblastoma multiforme.

Underhill Hunter R HR

Magnetic resonance in medicine 20170112 5

<h4>Purpose</h4>To develop a continuous-infusion dynamic MRI technique to characterize tumor-associated microvascular proliferation (MVP) in a rat brain model of glioblastoma multiforme.<h4>Methods</h4>The proposed model assumes effects due to tumor-associated MVP (eg, vascular permeability, K<sup>trans</sup> ; intravascular plasma fraction, v<sub>p</sub> ) cannot be individually separated and solves for a single parameter (k<sup>vasc</sup> ) that quantifies the T<sub>1</sub> -weighted contrast ...[more]

PMID: 28078795

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Project description:Microvascular anastomosis is a critical procedure in cerebral bypass surgeries. In some rare cases, the extraluminal interrupted technique is not optimal because the vessels are immobile and cannot be rotated, and anastomosis can be performed effectively through the intraluminal continuous suturing technique. The authors reported the application of the intraluminal continuous suturing technique in microanastomosis training with silicone tube, rat's common iliac arteries and abdominal aorta. A silicone tube with a diameter of 1.5 mm was used to practice microanastomosis in intraluminal continuous suturing technique. Then the technique was applied in side-to-side, end-to-side anastomoses of common iliac arteries and the end-to-end abdominal aorta anastomoses of rat. The suturing time and patency rates were compared with an alternative intraluminal continuous suturing technique and one-way-up interrupted suturing technique in silicone tube and rat vessel anastomoses. The intraluminal continuous suturing technique could be gained through practicing with silicone tube, and the technique has also been demonstrated effective in side-to-side, end-to-side anastomoses of common iliac arteries of rat and the abdominal aorta end-to-end anastomoses. In all the animal experimental groups with different suturing techniques, there was no difference between the patency rates, all the immediate patency rate was 100%. There was no significant suturing time difference between the two intraluminal continuous suturing techniques, but the two intraluminal continuous suturing techniques were faster than the interrupted technique. The intraluminal continuous suturing technique described in the study could be used as an efficient method for side-to-side, end-to-side and end-to-end anastomosis, especially under the situation the posterior wall of the anastomosis could not be rotated. Proficiency of the technique could be achieved through practicing in laboratory with silicone tube and live animals.

Dataset Information

A continuous-infusion dynamic MRI model at 3.0 Tesla for the serial quantitative evaluation of microvascular proliferation in an animal model of glioblastoma multiforme.

Publications

A continuous-infusion dynamic MRI model at 3.0 Tesla for the serial quantitative evaluation of microvascular proliferation in an animal model of glioblastoma multiforme.

Similar Datasets

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