Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection.

ABSTRACT: Gold nanoparticles (AuNP) dotted reduction graphene oxide (RGO-AuNP) is used as a platform for an aptamer biosensor to selectively detect 3,3'4,4'-polychlorinated biphenyls (PCB77). By anchoring aptamers onto the binding sites of RGO-AuNP and making use of the synergy effect of RGO and AuNP, the RGO-AuNP based biosensor exhibits superior analytical performances to AuNP based biosensor in terms of sensitivity and repeatability. The sensitivity of RGO-AuNP based aptamers (RGO-AuNP-Ap) biosensor (226.8??A cm-2) is nearly two times higher than that of Au based biosensors (AuNP-Ap/Au electrode, 147.2??A cm-2). The RGO-AuNP-Ap/Au biosensor demonstrated a linear response for PCB77 concentrations between 1?pg?L-1 and 10??g?L-1, with a low limit of detection (LOD) of 0.1?pg?L-1. The superb LOD satisfies the exposure thresholds (uncontaminated water?

SUBMITTER: Wu L 

PROVIDER: S-EPMC5507977 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature