Ontology highlight
ABSTRACT:
SUBMITTER: Bisiaux A
PROVIDER: S-EPMC5507989 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Bisiaux Aurélie A Boussier Jeremy J Duffy Darragh D Quintana-Murci Lluis L Fontes Magnus M Albert Matthew L ML
Frontiers in immunology 20170713
Bacillus Calmette-Guérin (BCG) is used as a vaccine and diagnostic test for tuberculosis, as well as immunotherapy in the treatment of bladder cancer. While clinically useful, the response to mycobacterial stimulation is complex and the induced protein signature remains poorly defined. We characterized the cell types directly engaged by BCG, as well as the induced cytokine loops that transmit signal(s) to bystander cells. Standardized whole-blood stimulations and mechanistic studies on single an ...[more]