Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection.
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ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC5508227 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection.
Xu Zhipeng Z Xu Lei L Li Wei W Jin Xin X Song Xian X Chen Xiaojun X Zhu Jifeng J Zhou Sha S Li Yong Y Zhang Weiwei W Dong Xiaoxiao X Yang Xiaowei X Liu Feng F Bai Hui H Chen Qi Q Su Chuan C
Nature communications 20170711
The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen infection. Here we show with mouse models of helminth Schistosoma japonicum infection and heat-inactivated Mycobacterium tuberculosis stimulation that SR-A is regulated by pathogens and suppresses IRF5 ...[more]
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