Ontology highlight
ABSTRACT:
SUBMITTER: Vu LP
PROVIDER: S-EPMC5508533 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Vu Ly P LP Prieto Camila C Amin Elianna M EM Chhangawala Sagar S Krivtsov Andrei A Calvo-Vidal M Nieves MN Chou Timothy T Chow Arthur A Minuesa Gerard G Park Sun Mi SM Barlowe Trevor S TS Taggart James J Tivnan Patrick P Deering Raquel P RP Chu Lisa P LP Kwon Jeong-Ah JA Meydan Cem C Perales-Paton Javier J Arshi Arora A Gönen Mithat M Famulare Christopher C Patel Minal M Paietta Elisabeth E Tallman Martin S MS Lu Yuheng Y Glass Jacob J Garret-Bakelman Francine E FE Melnick Ari A Levine Ross R Al-Shahrour Fatima F Järås Marcus M Hacohen Nir N Hwang Alexia A Garippa Ralph R Lengner Christopher J CJ Armstrong Scott A SA Cerchietti Leandro L Cowley Glenn S GS Root David D Doench John J Leslie Christina C Ebert Benjamin L BL Kharas Michael G MG
Nature genetics 20170424 6
The identity of the RNA-binding proteins (RBPs) that govern cancer stem cells remains poorly characterized. The MSI2 RBP is a central regulator of translation of cancer stem cell programs. Through proteomic analysis of the MSI2-interacting RBP network and functional shRNA screening, we identified 24 genes required for in vivo leukemia. Syncrip was the most differentially required gene between normal and myeloid leukemia cells. SYNCRIP depletion increased apoptosis and differentiation while delay ...[more]