Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC5508657 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Chemical science 20150910 12
Artificial DNA motifs as architectural scaffolds have been widely used to assemble a variety of nanoscale devices. Synthetic DNA nanostructures have accomplished mechanical switching in response to external stimuli, suggesting the promise of constructing a walking device that is being used in the field of biosensors. Here, we design a novel miRNA-responsive DNA walker biosensor based on strand displacement cascades and an enzymatic recycling cleavage strategy. By using miRNA as a driving force, ...[more]