Ontology highlight
ABSTRACT:
SUBMITTER: Montoya MM
PROVIDER: S-EPMC5508756 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Montoya Misty M MM Maul Julia J Singh Priti B PB Pua Heather H HH Dahlström Frank F Wu Nanyan N Huang Xiaozhu X Ansel K Mark KM Baumjohann Dirk D
Journal of immunology (Baltimore, Md. : 1950) 20170612 2
Th17 cell responses orchestrate immunity against extracellular pathogens but also underlie autoimmune disease pathogenesis. In this study, we uncovered a distinct and critical role for miR-18a in limiting Th17 cell differentiation. miR-18a was the most dynamically upregulated microRNA of the miR-17-92 cluster in activated T cells. miR-18a deficiency enhanced CCR6<sup>+</sup> RAR-related orphan receptor (ROR)γt<sup>+</sup> Th17 cell differentiation in vitro and increased the number of tissue Th17 ...[more]