Ontology highlight
ABSTRACT:
SUBMITTER: Caballero D
PROVIDER: S-EPMC5509111 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Caballero Daniel D Li Yuwen Y Fetene Jonathan J Ponsetto Julian J Chen Alyssa A Zhu Chuanlong C Braddock Demetrios T DT Bergwitz Clemens C
PloS one 20170713 7
Mutations in the proximal tubular sodium-dependent phosphate co-transporters NPT2a and NPT2c have been reported in patients with renal stone disease and nephrocalcinosis, however the relative contribution of genotype, dietary calcium and phosphate, and modifiers of mineralization such as pyrophosphate (PPi) to the formation of renal mineral deposits is unclear. In the present study, we used Npt2a-/- mice to model the renal calcifications observed in these disorders. We observed elevated urinary ...[more]