Ontology highlight
ABSTRACT:
SUBMITTER: Klose D
PROVIDER: S-EPMC5509223 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Klose Diana D Woitok Mira M Niesen Judith J Beerli Roger R RR Grawunder Ulf U Fischer Rainer R Barth Stefan S Fendel Rolf R Nachreiner Thomas T
PloS one 20170713 7
The antigen-specific targeting of autoreactive B cells via their unique B cell receptors (BCRs) is a novel and promising alternative to the systemic suppression of humoral immunity. We generated and characterized cytolytic fusion proteins based on an existing immunotoxin comprising tetanus toxoid fragment C (TTC) as the targeting component and the modified Pseudomonas aeruginosa exotoxin A (ETA') as the cytotoxic component. The immunotoxin was reconfigured to replace ETA' with either the granzym ...[more]