Ontology highlight
ABSTRACT:
SUBMITTER: Alonso-Dominguez JM
PROVIDER: S-EPMC5509313 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Alonso-Dominguez Juan M JM Casado Luis Felipe LF Anguita Eduardo E Gomez-Casares Maria Teresa MT Buño Ismael I Ferrer-Marín Francisca F Arenas Alicia A Del Orbe Rafael R Ayala Rosa R Llamas Pilar P Salgado Rocio N RN Osorio Santiago S Sanchez-Godoy Pedro P Burgaleta Carmen C Mahíllo-Fernández Ignacio I Garcia-Gutierrez Valentin V Steegmann Juan Luis JL Martinez-Lopez Joaquín J
PloS one 20170713 7
Patched homolog 1 gene (PTCH1) expression and the ratio of PTCH1 to Smoothened (SMO) expression have been proposed as prognostic markers of the response of chronic myeloid leukemia (CML) patients to imatinib. We compared these measurements in a realistic cohort of 101 patients with CML in chronic phase (CP) using a simplified qPCR method, and confirmed the prognostic power of each in a competing risk analysis. Gene expression levels were measured in peripheral blood samples at diagnosis. The PTC ...[more]