Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC5509478 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Ma X X Meng Z Z Jin L L Xiao Z Z Wang X X Tsark W M WM Ding L L Gu Y Y Zhang J J Kim B B He M M Gan X X Shively J E JE Yu H H Xu R R Huang W W
Oncogene 20170320 28
Inflammation is one of the major risk factors for cancer. Here, we show that calcium/calmodulin-dependent protein kinase II gamma (CAMK2γ) in intestinal epithelial cells (IECs) modulates inflammatory signals and promotes colitis-associated cancer (CAC) in mice. We have identified CAMK2γ as a downstream target of colitis-induced WNT5A signaling. Furthermore, we have shown that CAMK2γ protects against intestine tissue injury by increasing IEC survival and proliferation. Calcium/calmodulin-dependen ...[more]