Unknown

Dataset Information

0

Vitamin D insufficiency in neonatal hypoxic-ischemic encephalopathy.


ABSTRACT: BACKGROUND:Vitamin D has neuroprotective and immunomodulatory properties, and deficiency is associated with worse stroke outcomes. Little is known about effects of hypoxia-ischemia or hypothermia treatment on vitamin D status in neonates with hypoxic-ischemic encephalopathy (HIE). We hypothesized vitamin D metabolism would be dysregulated in neonatal HIE altering specific cytokines involved in Th17 activation, which might be mitigated by hypothermia. METHODS:We analyzed short-term relationships between 25(OH) and 1,25(OH)2 vitamin D, vitamin D binding protein, and cytokines related to Th17 function in serum samples from a multicenter randomized controlled trial of hypothermia 33 °C for 48?h after HIE birth vs. normothermia in 50 infants with moderate to severe HIE. RESULTS:Insufficiency of 25(OH) vitamin D was observed after birth in 70% of infants, with further decline over the first 72?h, regardless of treatment. 25(OH) vitamin D positively correlated with anti-inflammatory cytokine IL-17E in all HIE infants. However, Th17 cytokine suppressor IL-27 was significantly increased by hypothermia, negating the IL-27 correlation with vitamin D observed in normothermic HIE infants. CONCLUSION:Serum 25(OH) vitamin D insufficiency is present in the majority of term HIE neonates and is related to lower circulating anti-inflammatory IL-17E. Hypothermia does not mitigate vitamin D deficiency in HIE.

SUBMITTER: Lowe DW 

PROVIDER: S-EPMC5509506 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications


<h4>Background</h4>Vitamin D has neuroprotective and immunomodulatory properties, and deficiency is associated with worse stroke outcomes. Little is known about effects of hypoxia-ischemia or hypothermia treatment on vitamin D status in neonates with hypoxic-ischemic encephalopathy (HIE). We hypothesized vitamin D metabolism would be dysregulated in neonatal HIE altering specific cytokines involved in Th17 activation, which might be mitigated by hypothermia.<h4>Methods</h4>We analyzed short-term  ...[more]

Similar Datasets

| S-EPMC4613313 | biostudies-literature
| S-EPMC4297029 | biostudies-other
| S-EPMC3299861 | biostudies-other
| S-EPMC8797213 | biostudies-literature
| S-SCDT-10_1038-S44321-024-00079-1 | biostudies-other
| S-EPMC6579623 | biostudies-literature
| S-EPMC4568393 | biostudies-literature
| S-EPMC5288491 | biostudies-literature
| S-EPMC4753811 | biostudies-other
| S-EPMC6219383 | biostudies-literature