Ontology highlight
ABSTRACT:
SUBMITTER: Raza GS
PROVIDER: S-EPMC5509720 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Raza Ghulam Shere GS Putaala Heli H Hibberd Ashley A AA Alhoniemi Esa E Tiihonen Kirsti K Mäkelä Kari Antero KA Herzig Karl-Heinz KH
Scientific reports 20170713 1
Obesity and dyslipidemia are hallmarks of metabolic and cardiovascular diseases. Polydextrose (PDX), a soluble fiber has lipid lowering effects. We hypothesize that PDX reduces triglycerides and cholesterol by influencing gut microbiota, which in turn modulate intestinal gene expression. C57BL/6 male mice were fed a Western diet (WD) ±75 mg PDX twice daily by oral gavage for 14 days. Body weight and food intake were monitored daily. Fasting plasma lipids, caecal microbiota and gene expression in ...[more]