Ontology highlight
ABSTRACT:
SUBMITTER: Abdullah UB
PROVIDER: S-EPMC5510000 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Abdullah Ummi B UB McGouran Joanna F JF Brolih Sanja S Ptchelkine Denis D El-Sagheer Afaf H AH Brown Tom T McHugh Peter J PJ
The EMBO journal 20170612 14
During replication-coupled DNA interstrand crosslink (ICL) repair, the XPF-ERCC1 endonuclease is required for the incisions that release, or "unhook", ICLs, but the mechanism of ICL unhooking remains largely unknown. Incisions are triggered when the nascent leading strand of a replication fork strikes the ICL Here, we report that while purified XPF-ERCC1 incises simple ICL-containing model replication fork structures, the presence of a nascent leading strand, modelling the effects of replication ...[more]