Ontology highlight
ABSTRACT:
SUBMITTER: Durazo SA
PROVIDER: S-EPMC5510476 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Durazo Shelley A SA Kadam Rajendra S RS Drechsel Derek D Patel Manisha M Kompella Uday B UB
Pharmaceutical research 20110728 11
<h4>Purpose</h4>To determine the influence of drug physicochemical properties on brain mitochondrial delivery of 20 drugs at physiological pH.<h4>Methods</h4>The delivery of 8 cationic drugs (beta-blockers), 6 neutral drugs (corticosteroids), and 6 anionic drugs (non-steroidal anti-inflammatory drugs, NSAIDs) to isolated rat brain mitochondria was determined with and without membrane depolarization. Multiple linear regression was used to determine whether lipophilicity (Log D), charge, polarizab ...[more]