Ontology highlight
ABSTRACT:
SUBMITTER: Ho GT
PROVIDER: S-EPMC5510721 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Ho G-T GT Aird R E RE Liu B B Boyapati R K RK Kennedy N A NA Dorward D A DA Noble C L CL Shimizu T T Carter R N RN Chew E T S ETS Morton N M NM Rossi A G AG Sartor R B RB Iredale J P JP Satsangi J J
Mucosal immunology 20170412 1
The multidrug resistance-1 (MDR1) gene encodes an ATP-dependent efflux transporter that is highly expressed in the colon. In mice, loss of MDR1 function results in colitis with similarities to human inflammatory bowel diseases (IBD). Here, we show that MDR1 has an unexpected protective role for the mitochondria where MDR1 deficiency results in mitochondrial dysfunction with increased mitochondrial reactive oxygen species (mROS) driving the development of colitis. Exogenous induction of mROS acce ...[more]