Ontology highlight
ABSTRACT:
SUBMITTER: Wakeman DR
PROVIDER: S-EPMC5511045 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Wakeman Dustin R DR Hiller Benjamin M BM Marmion David J DJ McMahon Christopher W CW Corbett Grant T GT Mangan Kile P KP Ma Junyi J Little Lauren E LE Xie Zhong Z Perez-Rosello Tamara T Guzman Jaime N JN Surmeier D James DJ Kordower Jeffrey H JH
Stem cell reports 20170601 1
A major challenge for clinical application of pluripotent stem cell therapy for Parkinson's disease (PD) is large-scale manufacturing and cryopreservation of neurons that can be efficiently prepared with minimal manipulation. To address this obstacle, midbrain dopamine neurons were derived from human induced pluripotent stem cells (iPSC-mDA) and cryopreserved in large production lots for biochemical and transplantation studies. Cryopreserved, post-mitotic iPSC-mDA neurons retained high viability ...[more]