Ontology highlight
ABSTRACT:
SUBMITTER: Clark AT
PROVIDER: S-EPMC5511048 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Clark Amander T AT Gkountela Sofia S Chen Di D Liu Wanlu W Sosa Enrique E Sukhwani Meena M Hennebold Jon D JD Orwig Kyle E KE
Stem cell reports 20170601 1
Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult. Recent work has shown that primate PGCs can be differentiated from pluripotent stem cells; however, a bioassay that supports their identity as transplantable germ cells has not been reported. Here, we adopted a xenotransplantation assay by transplanting single-cell suspensions of human and nonhuman primate embryonic Macaca mulatta (rhesus ...[more]