Ontology highlight
ABSTRACT:
SUBMITTER: Song L
PROVIDER: S-EPMC5511105 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Song LouJin L Park Seon-Hye E SE Isseroff Yehuda Y Morikawa Kumi K Yazawa Masayuki M
Stem cell reports 20170622 1
L-type calcium channel Ca<sub>V</sub>1.2 plays an essential role in cardiac function. The gain-of-function mutations in Ca<sub>V</sub>1.2 have been reported to be associated with Timothy syndrome, a disease characterized by QT prolongation and syndactyly. Previously we demonstrated that roscovitine, a cyclin-dependent kinase (CDK) inhibitor, could rescue the phenotypes in induced pluripotent stem cell-derived cardiomyocytes from Timothy syndrome patients. However, exactly how roscovitine rescued ...[more]