Ontology highlight
ABSTRACT:
SUBMITTER: Feng JF
PROVIDER: S-EPMC5511115 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Feng Jun-Feng JF Liu Jing J Zhang Lei L Jiang Ji-Yao JY Russell Michael M Lyeth Bruce G BG Nolta Jan A JA Zhao Min M
Stem cell reports 20170629 1
Limited migration of neural stem cells in adult brain is a roadblock for the use of stem cell therapies to treat brain diseases and injuries. Here, we report a strategy that mobilizes and guides migration of stem cells in the brain in vivo. We developed a safe stimulation paradigm to deliver directional currents in the brain. Tracking cells expressing GFP demonstrated electrical mobilization and guidance of migration of human neural stem cells, even against co-existing intrinsic cues in the rost ...[more]