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Electrical Guidance of Human Stem Cells in the Rat Brain.


ABSTRACT: Limited migration of neural stem cells in adult brain is a roadblock for the use of stem cell therapies to treat brain diseases and injuries. Here, we report a strategy that mobilizes and guides migration of stem cells in the brain in vivo. We developed a safe stimulation paradigm to deliver directional currents in the brain. Tracking cells expressing GFP demonstrated electrical mobilization and guidance of migration of human neural stem cells, even against co-existing intrinsic cues in the rostral migration stream. Transplanted cells were observed at 3 weeks and 4 months after stimulation in areas guided by the stimulation currents, and with indications of differentiation. Electrical stimulation thus may provide a potential approach to facilitate brain stem cell therapies.

SUBMITTER: Feng JF 

PROVIDER: S-EPMC5511115 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Electrical Guidance of Human Stem Cells in the Rat Brain.

Feng Jun-Feng JF   Liu Jing J   Zhang Lei L   Jiang Ji-Yao JY   Russell Michael M   Lyeth Bruce G BG   Nolta Jan A JA   Zhao Min M  

Stem cell reports 20170629 1


Limited migration of neural stem cells in adult brain is a roadblock for the use of stem cell therapies to treat brain diseases and injuries. Here, we report a strategy that mobilizes and guides migration of stem cells in the brain in vivo. We developed a safe stimulation paradigm to deliver directional currents in the brain. Tracking cells expressing GFP demonstrated electrical mobilization and guidance of migration of human neural stem cells, even against co-existing intrinsic cues in the rost  ...[more]

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