Ontology highlight
ABSTRACT:
SUBMITTER: Liao C
PROVIDER: S-EPMC5511175 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20170714 1
The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a potential therapeutic target for endocrine, metabolic and stress-related disorders. However, many questions regarding the protein structure and dynamics of PAC1R remain largely unanswered. Using microsecond-long simulations, we examined the open and closed PAC1R conformations interconnected within an ensemble of transitional states. The open-to-closed transition can be initiated by "unzipping" the extr ...[more]