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Combining molecular typing and spatial pattern analysis to identify areas of high tuberculosis transmission in a moderate-incidence county in Taiwan.


ABSTRACT: In total, 303 randomly selected clinical Mycobacterium tuberculosis (MTB) isolates from 303 patients (collected January to December 2012) in central Taiwan were examined. The major lineages found were Beijing (N?=?114, 37.62%), Haarlem (N?=?76, 25.08%) and East African-Indian (EAI) (N?=?42, 13.86%). Notably, younger persons (?30 years old) were 6.58 times more likely to be infected with a Beijing genotype compared to older persons (>70 years) (p?

SUBMITTER: Chen YY 

PROVIDER: S-EPMC5511213 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Combining molecular typing and spatial pattern analysis to identify areas of high tuberculosis transmission in a moderate-incidence county in Taiwan.

Chen Yih-Yuan YY   Chang Jia-Ru JR   Wu Chih-Da CD   Yeh Yen-Po YP   Yang Shiu-Ju SJ   Hsu Chih-Hao CH   Lin Ming-Ching MC   Tsai Ching-Fang CF   Lin Ming-Shian MS   Su Ih-Jen IJ   Dou Horng-Yunn HY  

Scientific reports 20170714 1


In total, 303 randomly selected clinical Mycobacterium tuberculosis (MTB) isolates from 303 patients (collected January to December 2012) in central Taiwan were examined. The major lineages found were Beijing (N = 114, 37.62%), Haarlem (N = 76, 25.08%) and East African-Indian (EAI) (N = 42, 13.86%). Notably, younger persons (≤30 years old) were 6.58 times more likely to be infected with a Beijing genotype compared to older persons (>70 years) (p < 0.05). Combining molecular typing methods and ge  ...[more]

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