The dental phenotype of hairless dogs with FOXI3 haploinsufficiency.
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ABSTRACT:
SUBMITTER: Kupczik K
PROVIDER: S-EPMC5511229 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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The dental phenotype of hairless dogs with FOXI3 haploinsufficiency.
Kupczik Kornelius K Cagan Alexander A Brauer Silke S Fischer Martin S MS
Scientific reports 20170714 1
Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack of hair and abnormal tooth morphology. This has been attributed to a semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds. Here, we identified this FOXI3 variant in a historical museum sample of pedigreed hairless dog skulls by using ancient DNA extraction and present the associated dental phenotype. Unlike in the coated wild type dogs, the hairless do ...[more]
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