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Modifying Dendritic Cell Activation with Plasmonic Nano Vectors.

ABSTRACT: Dendritic cells (DCs) can acquire, process, and present antigens to T-cells to induce an immune response. For this reason, targeting cancer antigens to DCs in order to cause an immune response against cancer is an emerging area of nanomedicine that has the potential to redefine the way certain cancers are treated. The use of plasmonically active silver-coated gold nanorods (henceforth referred to as plasmonic nano vectors (PNVs)) as potential carriers for DC tumor vaccines has not been presented before. Effective carriers must be able to be phagocytized by DCs, present low toxicity, and induce the maturation of DCs-an early indication of an immune response. When we treated DCs with the PNVs, we found that the cell viability of DCs was unaffected, up to 200??g/ml. Additionally, the PNVs associated with the DCs as they were phagocytized and they were found to reside within intracellular compartments such as endosomes. More importantly, the PNVs were able to induce expression of surface markers indicative of DC activation and maturation, i.e. CD40, CD86, and MHC class II. These results provide the first evidence that PNVs are promising carriers for DC-based vaccines and warrant further investigating for clinical use.

SUBMITTER: Vang KB

PROVIDER: S-EPMC5511287 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Modifying Dendritic Cell Activation with Plasmonic Nano Vectors.

Vang Kieng Bao KB Safina Ingrid I Darrigues Emilie E Nedosekin Dmitry D Nima Zeid A ZA Majeed Waqar W Watanabe Fumiya F Kannarpady Ganesh G Kore Rajshekhar A RA Casciano Daniel D Zharov Vladimir P VP Griffin Robert J RJ Dings Ruud P M RPM Biris Alexandru S AS

Scientific reports 20170714 1

Dendritic cells (DCs) can acquire, process, and present antigens to T-cells to induce an immune response. For this reason, targeting cancer antigens to DCs in order to cause an immune response against cancer is an emerging area of nanomedicine that has the potential to redefine the way certain cancers are treated. The use of plasmonically active silver-coated gold nanorods (henceforth referred to as plasmonic nano vectors (PNVs)) as potential carriers for DC tumor vaccines has not been presented ...[more]

PMID: 28710434

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Project description:In this paper, a circular hybrid plasmonic waveguide-fed nano-antenna (CHPWFNA) has been introduced for operating at the standard telecommunication wavelength of 1,550 nm. For the first time, the dispersion relation of a circular hybrid plasmonic waveguide as the feed line of the proposed nano-antenna has been derived, analytically. To verify the accuracy of the analytical solution, two numerical techniques of finite element method (FEM) and finite-difference time-domain (FDTD) method have been used. Numerical results are well-matched with the theoretical ones. The characteristics of the CHPWFNA have been studied by two mentioned methods. The obtained realized gains (directivities) by the FDTD and FEM simulations are 9.03 dB (9.38 dBi) and 10.00 dB (10.32 dBi), respectively, at 1,550 nm wavelength. For on-chip point-to-point wireless link performance, the obtained quality factor by the FDTD method (FEM) is 63.97 (100). The obtained radiation characteristics and link performance reveal that at 1,550 nm, the proposed antenna has the best performance. Besides, the frequency bandwidth of the antenna (185-200 THz) covers the low-loss optical frequency range. Also, paying attention to the laser eye safety is so important. Consequently, the wavelength of 1,550 nm has been chosen as the target wavelength. Moreover, the array configuration has been studied and the directivity and realized gain have been obtained based on the array factor theory and numerical methods, which are agree with each other. The attained realized gain by the FDTD method (FEM) for the considered single row array, at 1,550 nm, is 11.20 dB (11.30 dB). There is a little difference between the numerical results due to the total mesh size, the grid size refinement and the relative error of the numerical methods convergence. Finally, as one of the most important challenges in fabrication is the gold surface quality, we have studied the effect of gold surface roughness and its pentagonal cross section on the antenna performance.

Dataset Information

Modifying Dendritic Cell Activation with Plasmonic Nano Vectors.

Publications

Modifying Dendritic Cell Activation with Plasmonic Nano Vectors.

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