Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5511515 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Li Jinxing J Angsantikul Pavimol P Liu Wenjuan W Esteban-Fernández de Ávila Berta B Thamphiwatana Soracha S Xu Mingli M Sandraz Elodie E Wang Xiaolei X Delezuk Jorge J Gao Weiwei W Zhang Liangfang L Wang Joseph J
Angewandte Chemie (International ed. in English) 20170120 8
The highly acidic gastric environment creates a physiological barrier for using therapeutic drugs in the stomach. While proton pump inhibitors have been widely used for blocking acid-producing enzymes, this approach can cause various adverse effects. Reported herein is a new microdevice, consisting of magnesium-based micromotors which can autonomously and temporally neutralize gastric acid through efficient chemical propulsion in the gastric fluid by rapidly depleting the localized protons. Coat ...[more]