Ontology highlight
ABSTRACT:
SUBMITTER: Zhang D
PROVIDER: S-EPMC5511552 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Cancer research 20170504 14
RAS and its downstream cascades transmit cellular signals, resulting in increased transcription of genes involved in cell growth and division. Protein-coding gene targets of RAS signaling have been characterized extensively, but long noncoding RNAs (lncRNA) regulated by these processes have not. Using a custom-designed lncRNA microarray, we identified the lncRNA <i>Orilnc1</i> as a genetic target of RAS that is critical for RAS oncogenicity. <i>Orilnc1</i> expression was regulated by RAS-RAF-MEK ...[more]