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Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes.

ABSTRACT: The three Actinobacteria strains Streptomyces platensis DSM 40041, Pseudonocardia autotrophica DSM 535, and Streptomyces fradiae DSM 40063 were described to selectively oxyfunctionalize several drugs. Here, we present their draft genomes to unravel their gene sets encoding promising cytochrome P450 monooxygenases associated with the generation of drug metabolites.

SUBMITTER: Grumaz C

PROVIDER: S-EPMC5511904 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes.

Grumaz Christian C Vainshtein Yevhen Y Kirstahler Philipp P Luetz Stephan S Kittelmann Matthias M Schroer Kirsten K Eggimann Fabian K FK Czaja Rico R Vogel Andreas A Hilberath Thomas T Worsch Anne A Girhard Marco M Urlacher Vlada B VB Sandberg Marcel M Sohn Kai K

Genome announcements 20170713 28

The three Actinobacteria strains Streptomyces platensis DSM 40041, Pseudonocardia autotrophica DSM 535, and Streptomyces fradiae DSM 40063 were described to selectively oxyfunctionalize several drugs. Here, we present their draft genomes to unravel their gene sets encoding promising cytochrome P450 monooxygenases associated with the generation of drug metabolites. ...[more]

PMID: 28705965

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