100K Pathogen Genome Project.
Ontology highlight
ABSTRACT:
SUBMITTER: Weimer BC
PROVIDER: S-EPMC5511910 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
The 100K Pathogen Genome Project is producing draft and closed genome sequences from diverse pathogens. This project expanded globally to include a snapshot of global bacterial genome diversity. The genomes form a sequence database that has a variety of uses from systematics to public health. ...[more]
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has limited the diversity of individuals in genomic datasets and led to reduced medical
relevance for a large proportion of the world’s population. Population-specific
reference genome datasets as well as genome-wide association studies in diverse
populations are needed to address this issue. Here we describe the pilot phase of the
GenomeAsia 100K Project. This includes a whole-genome sequencing reference
dataset from 1,739 individuals of 219 population groups and 64 countries across Asia.
We catalogue genetic variation, population structure, disease associations and
founder effects. We also explore the use of this dataset in imputation, to facilitate
genetic studies in populations across Asia and worldwide.
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