Ontology highlight
ABSTRACT:
SUBMITTER: Guo QN
PROVIDER: S-EPMC5512027 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Guo Qian-Nan QN Wang Hong-Dan HD Tie Li-Zhen LZ Li Tao T Xiao Hai H Long Jian-Gang JG Liao Shi-Xiu SX
BioMed research international 20170703
<h4>Background</h4>Congenital heart defect (CHD) is one of the most common birth defects in the world. The methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes are two of the most important candidate genes for fetal CHD. However, the correlations between the two genes and fetal CHD were inconsistent in various reports. Therefore, this study is aimed to evaluate the parental effects of the two genes on fetal CHD via three genetic polymorphisms, MTHFR 677C>T ( ...[more]